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The aflatoxin challenge can be addressed effectively and in a more sustainable and comprehensive fashion if it is mainstreamed in existing frameworks and structures, such as the Comprehensive Africa Agriculture Development Programme (CAADP) National Agriculture and Food Security Investment Plans (NAFSIPs). Other frameworks that can be used for mainstreaming aflatoxin issues include, inter alia, the African Health Strategy, Scaling Up Nutrition (SUN), national food safety laws and regulations, and local agricultural extension and community health programs. In 2014 and 2015, PACA will support its pilot countries’ efforts to mainstream aflatoxins and other food safety challenges into their CAADP NAFSIPs and relevant health and nutrition frameworks.